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Soligenix Announces Presentation and Poster at the 2017 Chemical and Biological Defense Science and Technology Conference in Long Beach, CA

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PRINCETON, N.J., Nov. 27, 2017 /PRNewswire/ — Soligenix, Inc. (Nasdaq: SNGX) (Soligenix or the Company), a late-stage biopharmaceutical company focused on developing and commercializing products to treat rare diseases where there is an unmet medical need, announced today that Dr. Oreola Donini, Chief Scientific Officer, will be presenting preclinical data from two of its biodefense development programs at the upcoming Chemical and Biological Defense Science and Technology Conference on November 28-30, 2017 to be held at the Long Beach Convention Center, Long Beach, CA.

Oral Presentation:

Innate Defense Regulators – Supercharging Antibiotic Treatment for Resistant or Unknown Infectious Disease presented by Dr. Oreola Donini, Chief Scientific Officer, Soligenix, Inc., on November 28, 2017 from 2:30-3:00 PM Pacific Standard Time (PST), Room 104A. The abstract is available here.

Poster Presentations:

Using Monoclonal Antibodies as Immune Correlates of Protection: Thermostable Ricin Toxin Vaccine Development attended by Dr. Oreola Donini, Chief Scientific Officer, Soligenix, Inc., on November 28, 2017 from 6:00-8:00 PM PST, Exhibit Hall B. The abstract is available here.

The presented results will address recent preclinical efficacy findings in two programs funded by the National Institute of Allergy and Infectious Diseases (NIAID), including:

SGX943 (dusquetide) in the treatment of antibiotic resistant infections including melioidosis, and RiVax®, a proprietary thermostable ricin toxin vaccine, in an inhalational model of ricin intoxication.

Dusquetide is an Innate Defense Regulator (IDR), which enhances the anti-infective activity of the innate immune system while down-modulating inflammation.  Since IDRs do not directly target the bacteria, it is unlikely to engender resistance and is complementary with current antibiotic regimens.  Soligenix has recently reported the results of a Phase 2 clinical study using dusquetide in the treatment of oral mucositis in head and neck cancer patients undergoing chemoradiation therapy.  In addition to demonstrating a reduction in the duration of oral mucositis in these patients, dusquetide treatment was also associated with a reduced incidence of reported infections.   

RiVax® is the Company’s candidate vaccine for the prevention of death following exposure to ricin toxin using a unique antigen that is completely devoid of the toxic activity of ricin.  When formulated using Soligenix’s proprietary ThermoVax® technology, RiVax® has demonstrated significantly enhanced thermostability and 100% protection in preclinical aerosol challenge models. Moreover, potential correlates of immune protection have been identified, which is a requirement of the “Animal Rule” to pursue approval of RiVax®.

Preclinical studies for SGX943 (grant #1R43 AI108175-01A1)

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